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Because Your Gut Shouldn’t Be the Drama Queen in the Room

Bloating, brain fog, and fatigue? This probiotic helps bring your gut and your life back to balance.

Packed with 7 clinically studied probiotic strains and prebiotic fibers to support digestion, immunity, nutrient absorption, and overall microbiome health.
This is what gut support looks like when it actually works.
Probiotic
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Your Gut’s Not Just About Digestion. It Runs the Whole Show.

Bloating? Brain fog? Random mood swings? That might be your microbiome waving a white flag.

Your gut is home to trillions of bacteria that affect how you feel, think, digest, absorb nutrients and yes, even how you recover from workouts and fight off that random office cold.


A strong gut means strong digestion, steady energy, sharper focus, and better recovery because it’s all connected.

That’s why we created a custom probiotic blend, carefully selected with clinically studied strains that show real benefits to digestion, immunity, nutrient absorption, and overall microbiome health.

We added a Prebiotic Blend to feed the good bacteria already living in your gut. (Because thriving gut health is about adding good guys and keeping them fed, strong, and ready for anything too.)

Whether you’re dealing with bloating, digestive “guesswork,” or just want to actually feel the benefits of the healthy foods you’re eating, Twenty2 Probiotic helps restore balance where it matters most.

Seven Clinically Studied Probiotic Strains

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Lactobacillus Plantarum: Known for helping reduce bloating and IBS symptoms (96% of participants in a study felt improvement). Also supports immune health and gut balance.
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Lactobacillus Acidophilus: Supports nutrient absorption, helps break down dairy, and contributes to overall immune strength and vaginal health.
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Lactobacillus Gasseri: Linked to healthy weight management and found naturally in breast milk — gentle and powerful.
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Bifidobacterium Lactis & Bifidum: Workhorses for digestion, immune system support, and improving constipation. These strains have been in your body since birth and your gut loves them for a reason.
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Bifidobacterium Longum & Breve: Help protect the gut lining, reduce inflammation, and support responses to stress, allergies, and even skin health.
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Prebiotic Blend

Prebiotics are nondigestible fibers that feed the good bacteria in your gut. They help create a thriving, diverse microbiome that supports digestion, reduces bloating, and keeps your gut feeling like it’s on your side for once.

Because better digestion doesn’t just mean a better stomach.
It means better energy. Better immunity. Better everything.

Key Ingredients

Probiotic Blend + -
  • Feed the good bacteria, helping them multiply and thrive in your digestive tract creating an environment where beneficial bacteria can continue to flourish.
Lactobacillus Plantarum + -
  • Improves digestion, immunity, and overall health
  • Clinical studies show 96% of people noticed improvement in IBS symptoms
  • Produces antibodies that target harmful bacteria in the gut
  • Helps alleviate bloating and intestinal discomfort
Lactobacillus Acidophilus + -
  • Supports nutrient absorption and digestion of dairy foods
  • Bolsters the immune system
  • May help alleviate mild constipation and gastrointestinal problems
Lactobacillus Gasseri + -
  • Has been connected to supporting weight management
  • Helps maintain healthy gut barrier function
Bifidobacterium Lactis + -
  • One of the most versatile strains found in yogurt and fermented milk
  • Supports digestion, immune system function, and relief from constipation
Bifidobacterium Bifidum + -
  • One of the most abundant strains found in the gut from infancy
  • Supports digestion, immune health, and lactose digestion
Bifidobacterium Longum + -
  • Helps protect intestinal walls from harmful bacteria
  • Supports digestion, immune health, and constipation relief
  • May support healthy responses to stress
Bifidobacterium Breve + -
  • Supports digestive health, may help with allergies, and aids immune system function
  • Makes up the majority of bacteria in breastfed babies
  • Some studies show support for respiratory, skin, and vaginal health
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Probiotic-Default Title
Why Choose our Probiotic
Feature / Benefit
Brand A
Brand B
Brand C
Clinically Studied Strains
Yes
None
(some)
None
Custom 7-Strain Blend
Yes
(3–4 generic strains)
Yes
Yes
Includes Prebiotics for Gut Support
Yes
None
None
None
Strains Targeting Digestion
& Bloating Relief
Yes
(basic relief)
(mild claims)
Yes
Strains Supporting Mood,
Skin & Immunity
Yes
None
(minimal)
None
Lactobacillus + Bifidobacterium
Synergy
Yes
(Lactobacillus only)
Yes
Yes
Free of Fillers & Artificial Additives
Yes
None
None
None
Third-Party Tested for Purity & Potency
Yes
None
None
None

Customer Reviews

Based on 163 reviews
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(161)
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A
Angelica Savage
Women's Health Need!

This resolved issues I as having and will now never go without this probiotic!

M
Margarita Garcia
Great!

I had started taking these back in 2023 when I got diagnosed with LCV and I was taking steroids and antibiotics!! Then once again these past few months and helped tremendously with my stomach after finishing my antibiotics!!

M
Mo
These are amazing!

I was looking for a probiotic that would help with stomach problems that I have, and these definitely delivered! They also helped with bloating a little bit which is a huge plus. I feel like the unique blend of probiotic and prebiotic strains have really benefitted my overall health. I usually will take just 2 capsules, not the recommended 3, and get great results. I will definitely keep buying these. They are a great product from a great company!

F
F.G.

Can’t go with out these! Best product. Only thing that makes me go regularly

A
Andrea

Love these probiotics. I take them at night if feeling bloated or if I eat something that bloats me up and gives me gas.

Frequently Asked Questions

Product Overview

Twenty2 Nutrition's Probiotic stands apart from other supplements in several important ways:

  • Custom 7-Strain Formula: Rather than focusing solely on high bacterial counts, we've carefully selected seven specific probiotic strains that work synergistically to provide comprehensive gut support. Each strain has been chosen based on scientific research supporting its specific benefits.
  • Prebiotic + Probiotic Combination: Our formula includes not just probiotics but also prebiotics — specialized fibers that feed beneficial bacteria. This creates a complete microbiome support system rather than just adding bacteria alone.
  • Strain-Specific Benefits: Each bacterial strain in our formula has been selected for particular health benefits, from improving digestion to supporting immune function to potentially aiding in weight management.
  • Quality Guaranteed: Our probiotics are manufactured in a GMP-certified facility that exceeds FDA standards, with each batch third-party tested for potency and purity.
  • Balanced Approach: We've included both Lactobacillus and Bifidobacterium strains to support different areas of the digestive tract for comprehensive gut health support.
  • Scientifically-Backed Strains: We only include bacterial strains with research supporting their benefits, not generic or unproven varieties.

This thoughtful, comprehensive approach to gut health makes our Probiotic a superior choice for those seeking real, noticeable benefits.

Regular use of Twenty2 Nutrition's Probiotic may provide numerous health benefits:

  • Improved Digestive Health: Support for regular bowel movements, reduced bloating, and better overall digestive comfort.
  • Enhanced Immune Function: Approximately 70% of your immune system resides in your gut. Our probiotic helps maintain a healthy gut barrier and supports immune cell activity.
  • Better Nutrient Absorption: A balanced microbiome helps your body more efficiently extract and utilize nutrients from the foods you eat.
  • Reduced Digestive Discomfort: Many users report less gas, bloating, and irregularity with consistent probiotic use.
  • Mood Support: Emerging research shows connections between gut health and mood regulation through the gut-brain axis.
  • Skin Health: Some probiotic strains may help with skin concerns by addressing the gut-skin connection.
  • Recovery After Antibiotics: Helps restore beneficial bacteria that may be depleted after antibiotic treatment.
  • Balanced Microbiome: Creates diversity within the gut microbiome, supporting the balance of beneficial bacteria against potentially harmful microorganisms.

Consistent daily use is key to experiencing these benefits as probiotics work gradually to improve gut ecology over time.

Absolutely! While many people start taking probiotics to address specific digestive concerns, Twenty2 Nutrition's Probiotic offers benefits even for those with normal digestion:

  • Preventative Support: Maintaining a healthy gut microbiome before problems arise is much easier than correcting imbalances later.
  • Immune System Support: Since approximately 70% of your immune system resides in your gut, supporting your microbiome helps maintain robust immune function.
  • Overall Wellness: A balanced gut microbiome contributes to many aspects of health beyond digestion, including energy levels, skin health, and even mood regulation.
  • Dietary Support: If you don't always eat a perfect diet (and who does?), probiotics can help support your gut despite occasional dietary indulgences or limitations.
  • Environmental Protection: Our modern environment contains many factors that can disrupt gut flora — from chlorinated water to preservatives. Probiotics provide ongoing protection against these everyday challenges.

Many customers without specific digestive complaints report benefits like improved energy, better stress resilience, clearer skin, and an overall enhanced sense of well-being when taking our Probiotic regularly.

Usage Guidelines

For optimal results with Twenty2 Nutrition's Probiotic:

  • Consistency is Key: Take one capsule daily at approximately the same time each day to maintain consistent levels of beneficial bacteria.
  • With or Without Food: Our probiotic can be taken either with food or on an empty stomach, depending on your preference. Some people find taking it with food helps minimize any potential adjustment symptoms.
  • Morning Routine: Many users prefer taking their probiotic in the morning as part of their daily wellness routine.
  • Before Bed: Others prefer taking it in the evening or before bed when digestive activity is naturally slower, allowing more time for the probiotics to establish themselves.
  • With Antibiotics: If you're taking antibiotics, continue your probiotic but separate the timing by at least 2 hours to prevent the antibiotic from affecting the probiotic bacteria.
  • During Travel: Maintain your probiotic routine while traveling to help support gut health during dietary changes and new environments.

The most important factor is daily consistency rather than specific timing. Find a routine that works for you and stick with it for best results.

Twenty2 Nutrition's Probiotic is formulated to be gentle on the digestive system. Most users experience no digestive discomfort when starting our probiotic. However, it's important to understand:

  • Initial Adjustment Period: Some individuals may experience mild, temporary changes in digestion when first starting any probiotic as the gut microbiome begins to rebalance. This is actually a sign that the product is working to create positive changes in your gut environment.
  • Typically Mild and Temporary: If any adjustment symptoms occur, they're usually mild (slight bloating or gas) and typically resolve within a few days as your body adapts to the beneficial bacteria.
  • Minimizing Adjustment: Starting with every other day for the first week can help minimize any adjustment period if you have a particularly sensitive system.
  • Prebiotic Component: Our formula contains prebiotics (food for beneficial bacteria) which are gentle but may cause slight bloating for some individuals with very sensitive digestive systems as their gut adapts.
  • Long-Term Benefits: After any initial adjustment, most users report significantly less bloating and gas than before they started the probiotic, as gut balance improves.

If you experience any significant discomfort, we recommend reducing to half the recommended serving temporarily and gradually increasing as your system adjusts.

Probiotics are generally considered safe during pregnancy and breastfeeding, and may actually provide benefits during these important life stages. However, as with any supplement during pregnancy or lactation:

  • Consult Your Healthcare Provider: Always discuss any supplements with your obstetrician, midwife, or healthcare provider before beginning, as individual circumstances may vary.
  • Potential Benefits: Research suggests probiotics may help reduce the risk of pregnancy-related digestive issues, support maternal immune function, and potentially reduce the risk of certain pregnancy complications.
  • Breastfeeding Support: Probiotics may help support the mother's microbiome, which can indirectly benefit infant gut health through breastfeeding.
  • Quality Matters: Twenty2 Nutrition's commitment to quality, purity testing, and carefully selected strains makes our probiotic a premium choice when supplementation during these crucial times is approved by your healthcare provider.

Many healthcare providers are now recommending probiotic supplementation during pregnancy and breastfeeding, but individual medical advice should always take precedence.

The timeline for experiencing benefits from Twenty2 Nutrition's Probiotic varies depending on your individual gut health, diet, lifestyle, and the specific benefits you're looking for:

  • Digestive Comfort: Many users report improvements in gas, bloating, and regularity within 2-4 weeks of consistent use.
  • Immune Support: Enhanced immune function may be noticed during the first cold and flu season after beginning supplementation.
  • Antibiotic Recovery: If taking after antibiotics, you may notice faster recovery of normal digestion compared to not using probiotics.
  • Long-Term Benefits: Some of the more significant benefits to overall wellness and gut health continue to develop over 2-3 months of consistent use.
  • Individual Variation: Those with significant gut imbalances may notice more dramatic improvements than those who already have relatively good gut health.

For optimal results, we recommend:

  1. Take the probiotic daily without missing doses
  2. Support with a diet rich in fruits, vegetables, and fiber
  3. Minimize processed foods and excessive sugar
  4. Allow at least 30 days of consistent use to evaluate initial benefits
  5. Continue for at least 90 days for more comprehensive gut rebalancing

Remember that probiotics work gradually to improve the gut ecosystem, not as an immediate quick fix.

No, Twenty2 Nutrition's Probiotic does not require refrigeration. Our formula has been specifically developed with shelf-stable strains that maintain potency at room temperature. This offers several advantages:

  • Convenience: No need to worry about refrigeration when traveling or at work
  • Consistent Potency: Formulated to maintain bacterial viability through the entire shelf life
  • Quality Assurance: We regularly test for potency to ensure the stated CFU (colony forming units) count remains effective until the expiration date

For optimal storage:

  • Keep in a cool, dry place away from direct sunlight
  • Avoid exposure to excessive heat or humidity
  • Keep the bottle tightly closed when not in use
  • Store at temperatures below 77°F (25°C) for maximum shelf life

While refrigeration isn't necessary, it won't harm the product and may slightly extend shelf life beyond the stated expiration date if you prefer to refrigerate.

Product Specifics

Twenty2 Nutrition's Probiotic is formulated with dietary preferences and restrictions in mind:

  • Gluten-Free: Yes, our Probiotic is completely free from gluten and is safe for those with celiac disease or gluten sensitivity.
  • Non-GMO: Yes, all ingredients in our Probiotic are derived from nongenetically modified sources.
  • Vegetarian: Yes, our Probiotic is suitable for vegetarian diets.
  • Vegan: Our Probiotic formulation is almost entirely plant-based, but some of the bacterial cultures may have been initially grown on media that could contain trace dairy-derived nutrients during the manufacturing process. While the final product contains negligible to no dairy, those following strict vegan diets may want to consider this.
  • Allergen Information: Produced in a facility that processes milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soy. However, strict protocols are in place to prevent cross-contamination.
  • Free From: No artificial colors, flavors, sweeteners, or preservatives. Contains no soy, no added sugar, and no unnecessary fillers.

If you have specific dietary concerns or severe allergies, please contact our customer support team for the most current and detailed information about our manufacturing processes.

Prebiotics are specialized plant fibers that act as food for the beneficial bacteria (probiotics) in your gut. Twenty2 Nutrition's Probiotic includes prebiotics because they create a synergistic effect that makes the probiotic bacteria more effective:

  • Nourishes Beneficial Bacteria: Prebiotics feed the good bacteria, helping them multiply and thrive in your digestive tract.
  • Selective Support: Unlike regular fiber, prebiotics specifically nourish beneficial bacteria while providing minimal nutrition to harmful bacteria.
  • Enhanced Colonization: Prebiotics help ensure the probiotic bacteria in our formula can establish themselves more effectively in your gut.
  • Long-Term Benefits: The inclusion of prebiotics helps create an environment where beneficial bacteria can continue to flourish even between doses.
  • Comprehensive Approach: This prebiotic + probiotic combination (sometimes called a "synbiotic") provides a more complete approach to gut health than probiotics alone.

The specific prebiotic blend in our formula includes fibers that resist digestion in the upper gastrointestinal tract, reaching the colon intact where they can be fermented by beneficial bacteria. This thoughtful addition is part of what makes our formula so effective for supporting overall gut health.

Absolutely. Quality and safety are top priorities for all Twenty2 Nutrition products, and our Probiotic undergoes rigorous testing:

  • GMP-Certified Manufacturing: Produced in a Good Manufacturing Practices (GMP) certified facility that exceeds FDA standards.
  • Third-Party Testing: Each batch undergoes independent laboratory testing to verify potency (bacterial count), purity, and freedom from contaminants.
  • Strain Verification: Testing confirms the identity and viability of each bacterial strain in our formula.
  • Contaminant Screening: Tested for potential contaminants including heavy metals, pesticides, and microbial impurities.
  • Potency Verification: CFU (colony forming unit) counts are verified to ensure you're getting the full potency listed on the label.
  • Stability Testing: Our formula undergoes stability testing to ensure potency through the entire shelf life of the product.
  • Allergen Controls: Strict protocols minimize risk of cross-contamination with common allergens.

Additional Questions

Yes, Twenty2 Nutrition's Probiotic can be safely combined with most other supplements as part of a comprehensive wellness routine. This versatility makes our Probiotic easy to incorporate into even the most comprehensive supplement regimen.

While Twenty2 Nutrition's Probiotic contains strains that are generally considered safe for children, our product is formulated and dosed specifically for adults. If you're considering probiotics for children:

  • Consult a Pediatrician: Always speak with your child's healthcare provider before introducing any supplement.
  • Age Considerations: For older children and teenagers (generally 12+), the adult formula may be appropriate with healthcare provider approval, potentially at a reduced dose.
  • Specific Needs: Children have different microbiome needs than adults, and a pediatric-specific probiotic formula might be more appropriate.
  • Size-Appropriate Dosing: If approved by a healthcare provider, older children may benefit from a reduced dose (such as every other day or opening the capsule and using a portion of the contents mixed with food).
  • Swallowing Capability: Consider whether your child can comfortably swallow capsules before purchasing.

We prioritize safety and appropriate use of our supplements, which is why we recommend consulting with a qualified healthcare provider for personalized guidance regarding children's use.